Modern strategies of targeted migraine therapy

Migraine is a chronic common neurological disorder. It an extremely disabling and significantly reduces the quality of life patients. Developments field fundamental research functional neuroimaging studies have improved understanding pathophysiology migraine. New specific drugs methods treatment appeared. They reduced severity headache attacks course disease. Therefore aim this work to analyze summarize information modern professional literature Data on neurophysiological features brain in migraine, emergence with other therapeutic targets, such as glutamate, amylin, adrenomedullin, orexins, pituitary adenylate cyclase-activating polypeptide are presented. Recommendations given for emergency migraine attack, depending degree maladaptation patient, concomitant symptoms, diseases patient's response treatment. Prophylactic can be divided into first-, second- third-line drugs, but choice order their use depend local practical recommendations availability individual regions cost. Efficacy, safety new therapy discussed molecules targeting calcitonin gene-related peptide (hepants monoclonal antibodies) serotonin 5-HT1F receptor agonists (ditans). Diagnosis clinical management worldwide remain suboptimal. A large number lead deeper neurobiology disorder, search that more adapted needs patients fundamentally change approach Keywords: peptide, therapy, hepants, antibodies, ditans.